Curso Abierto “Sistemas de Gestión Integrados de Calidad, Ambiente y Seguridad – Salud Ocupacional”

3, 5, 10 y 12 de Julio del 2018 – Santiago de Chile, Impartido para la Universidad del Desarrollo.

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    The use of corticosteroids is associated with a wide range of adverse effects, which
    can occur due to their potent glucocorticoid activity.
    The following are key points to consider:

    Adrenal Suppression

    Long-term or high-dose corticosteroid therapy may suppress the hypothalamic-pituitary-adrenal
    (HPA) axis, leading to reduced production of endogenous cortisol.
    This can result in:

    Cortisol deficiency (e.g., adrenal insufficiency)

    Adrenal atrophy

    Thromboembolism and Vascular Disruption

    Corticosteroids can contribute to hypercoagulation, increasing the risk of:

    Deep vein thrombosis (DVT)

    Pulmonary embolism

    Atherosclerosis

    Metabolic Disturbances

    Changes in metabolism include:

    Lipodystrophy

    Fatty liver

    Hyperglycemia and insulin resistance

    Musculoskeletal Effects

    Corticosteroids can lead to:

    Osteoporosis (due to reduced bone density)

    Amygdala enlargement

    Proximal muscle weakness

    Dermatological Adverse Effects

    The skin may experience:

    Acneiform eruptions

    Facial discoloration

    Hypertrichosis (excess hair growth)

    Others

    Additional potential effects include:

    Immunosuppression

    Eye changes (e.g., posterior subcapsular cataracts)

    Neuropathy

    Key Considerations

    Risk factors for corticosteroid adverse effects include:

    High doses or prolonged therapy

    Individual susceptibility

    Concurrent use of other medications (e.g., warfarin, NSAIDs)

    It is essential to weigh the benefits and risks of corticosteroid therapy and consider alternative
    treatments when possible.

    Introduction

    Corticosteroids are a class of drugs commonly used
    in the treatment of various inflammatory conditions, immune disorders, and other
    medical conditions. While these medications can be highly
    effective, they are also associated with a spectrum
    of potential adverse effects. Understanding these effects is critical for healthcare providers to safely and effectively manage patient care.

    Account

    Corticosteroids are derived from cholesterol and function as potent anti-inflammatory agents through their ability to suppress the immune
    response and modulate the activity of cells involved
    in inflammation. Their widespread use necessitates a thorough understanding of both
    their therapeutic benefits and potential side effects.

    Bookshelf

    The NCBI Bookshelf StatPearls provides a comprehensive resource for healthcare professionals to access
    information on drug dosing, indications, adverse effects, and
    other clinical considerations. This tool is an invaluable resource
    for staying updated on the latest guidelines and evidence-based practices in therapeutics.

    StatPearls

    The NCBI Bookshelf StatPearls platform is a widely used clinical decision-making tool
    that offers detailed information on various drugs, including corticosteroids.
    It allows users to quickly access key details such as indications, dosage guidelines, adverse effects,
    and patient monitoring strategies.

    Corticosteroid Adverse Effects

    Adverse effects associated with corticosteroid use can range from mild to
    severe and include a variety of clinical presentations.

    Common side effects include:
    – Glucocorticoid Resistance: A rare condition where the body’s cells become unresponsive to the therapeutic effects of corticosteroids, often leading to treatment failure.

    – Adrenal Suppression: Long-term use can suppress the hypothalamic-pituitary-adrenal (HPA) axis, potentially
    causing Addisonian crisis in susceptible individuals.

    – Thromboembolic Events: An increased risk of blood clots,
    which can lead to serious complications such as deep vein thrombosis and pulmonary embolism.

    – Moon Face Syndrome: A rare condition characterized by a distortion of facial features
    due to the redistribution of fat in the face.

    Authors

    The authors of this article are healthcare professionals with expertise in pharmacology, internal medicine, and clinical
    practice. Their contributions ensure that the information presented is evidence-based,
    accurate, and relevant to clinical practice.

    Affiliations

    The affiliations of the authors reflect their institutional roles and areas
    of research expertise. This information provides readers with context about the qualifications and experience of those
    contributing to the article.

    Continuing Education Activity

    This activity serves as a continuing education opportunity for healthcare professionals to enhance their knowledge and
    skills in the use of corticosteroids and the management of associated adverse effects.

    Indications

    Corticosteroids are used in the treatment of a wide range of
    conditions, including inflammatory bowel disease (IBD), autoimmune diseases such as rheumatoid arthritis,
    and allergic disorders like asthma and chronic obstructive pulmonary disease (COPD).
    Their efficacy in these conditions makes them a cornerstone
    in modern therapeutic medicine.

    Mechanism of Action

    Corticosteroids exert their therapeutic effects by binding to
    glucocorticoid receptors located on the surface of target cells.

    This interaction leads to the suppression of pro-inflammatory genes, thereby reducing the
    severity of inflammatory reactions and immune responses.

    Administration

    Corticosteroids are typically administered orally or via
    inhalation, depending on the specific indication. Intravenous and intramuscular
    routes are also used in certain cases. Proper dosing and route selection are critical to
    achieving therapeutic benefits while minimizing adverse effects.

    Adverse Effects

    The risk of corticosteroid-related adverse effects is dose-dependent and increases
    with the duration of treatment. Monitoring for common and serious side effects
    is essential.

    Contraindications

    Corticosteroids are contraindicated in individuals with a history of hypersensitivity to the
    drug, active or inactive tuberculosis (due to the risk of reactivation), and certain genetic conditions
    that predispose to adrenal insufficiency.

    Monitoring

    Close monitoring of patients receiving corticosteroid therapy is necessary to
    assess therapeutic response and detect adverse effects early.
    Regular laboratory tests, including serum cortisol levels
    and blood counts, can help guide adjustments in treatment.

    Toxicity

    Corticosteroid toxicity refers to the harmful effects that occur when the body is exposed
    to excessive or prolonged levels of these hormones.
    This toxicity can manifest as a variety of clinical symptoms, including muscle wasting,
    bone demineralization, and the development of Cushings syndrome.

    Enhancing Healthcare Team Outcomes

    Effective communication and collaboration among healthcare team members are essential for optimizing patient outcomes in the context of corticosteroid therapy.
    Regularly reviewing treatment plans and monitoring for adverse effects can help ensure that patients receive safe,
    effective care.

    Review Questions

    To test your understanding of this article, consider answering
    the following questions:
    1. Which condition is associated with an increased risk of thromboembolic events in corticosteroid users?

    a) Glucocorticoid resistance
    b) Adrenal suppression
    c) Thromboembolic events
    d) Moon face syndrome

    2. What is the primary mechanism of action for corticosteroids in inflammatory
    conditions?
    a) Inhibiting cytokine production
    b) Blocking transcription factors involved in inflammation
    c) Suppressing immune responses
    d) Allowing cells to heal more quickly

    3. Which route of administration is commonly used for corticosteroid therapy?

    a) Intravenous
    b) Subcutaneous
    c) Oral
    d) Inhaled

    References

    The information in this article is based on the NCBI Bookshelf
    StatPearls resource. For further reading and
    detailed guidelines, please refer to the following reference:

    – NCBI Bookshelf – StatPearls Internet. U.S. National Library
    of Medicine.

    Views

    The views expressed in this article are those of the authors and do not necessarily represent the views or policies of the institutions or organizations with which
    they are affiliated.

    In This Page

    – Account: Overview of corticosteroid pharmacology and clinical use.

    – Bookshelf: Access to detailed drug information via NCBI StatPearls.

    – StatPearls: A clinical decision-making tool for healthcare providers.

    Bulk Download

    For bulk downloads or further access to the content, please refer to the related information section below.

    Related Information

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    This is a typical response when injecting, occurring roughly 20% of the time in our experience. This is not a dangerous side impact, despite it being an anxious expertise for novices. Certain steroids may be painful to inject, such as Testosterone propionate, while other steroids are administered more smoothly. Muscle soreness is also frequent, which may be experienced deep within the muscle and might last for hours or days. There are, however, exceptions to this rule, with injectable steroids similar to Testosterone suspension having a detection time of simply 1-2 days. Beneath is a table comparing the detection time of oral vs. injectable steroids.
    Anadrol is a a lot stronger steroid, and it helps you acquire plenty of muscle very quickly. Oxymetholone will not be as widely identified for joint aid as nandrolone. Nevertheless, research have proven that it can aid within the synthesis of anti-inflammatory metabolites (9). I’m not a fan of 19-nors given the potential sexual and mental side effects, but they are good mass builders. Don’t trouble with the Mast if it is a cycle for power and your bf isn’t very low, Mast is mostly beauty in my expertise. Laws and laws will range internationally in phrases of buying and utilizing anabolic steroids like Anavar.
    It’s necessary to consult with a medical skilled before combining any medications or dietary supplements. Bodybuilders all over the world prioritize often working out to realize strength. Anavar, or Oxandrolone, is one of the most wished steroids in the bodybuilding world because of its nice advantages. Let’s look into how Anavar can help you accomplish power gains. That is dependent upon private preference and what targets you wish to achieve. It’s finest to take into accounts your state of health – including any medical circumstances – when deciding which steroid to make use of. Combining both could help cancel out any dangerous side-effects whereas enhancing their respective advantages.

    References:

    https://empleos.contatech.org/employer/anavar-for-women-side-effects/

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